Anisocoria treatment is determined and administered following an accurate diagnosis of the underlying cause of the condition. In cases of physiological anisocoria, where it does not arise from another disease, treatment is generally not required. However, if anisocoria is found to be due to a pathological cause, a specific treatment method targeting that cause is planned. The primary methods that can be employed in anisocoria treatment are as follows:

* If a tumor causing nerve compression is present, surgical intervention may be necessary.
* In the event of an eye injury, surgical operation or medical treatment may be applied depending on the severity of the injury.
* For conditions like glaucoma, medication or surgical options are considered to control intraocular pressure.
* If anisocoria develops due to a medication, it may be necessary to change the medication or adjust its dosage.
* If it originates from migraines or cluster headaches, the underlying migraine treatment is applied.
* If inflammation is present in the body, anti-inflammatory drugs such as antibiotics, antiviral medications, or steroids may be used.