The symptoms of Tetralogy of Fallot can vary and generally differ depending on the child's age.

During the postnatal period, no significant problems may be observed; however, a heart murmur heard during an examination by a pediatrician can be one of the first signs of Tetralogy of Fallot.

During infancy, cyanotic attacks (bluing/bluish discoloration) gradually increase. Especially bluing that begins during the nursing period can become more prominent when the child reaches one year of age. Sudden and severe bluing accompanied by body stiffening after crying or defecation (hypoxic spell) is a condition requiring urgent intervention. In such cases, if anemia is present, iron therapy should be initiated, and medication should be administered to prevent recurrence of the hypoxic spells.

As the child grows, "clubbed fingers" may develop, characterized by the nail bed appearing purple and bulging like a watch glass on the fingers and toes.

In older children, symptoms such as easy fatigue, the need for rest, and the desire to squat may suggest Tetralogy of Fallot.

In approximately 10% of newborn Tetralogy of Fallot cases, complete obstruction (pulmonary atresia) may be present in the heart valve from which the pulmonary artery emerges. In these infants, rapidly increasing bluing and metabolic acidosis after birth require urgent intervention with cardiac catheterization or open-heart surgery.

In some cases of Tetralogy of Fallot, especially within the first year, symptoms may not be observed at all. In conditions referred to as "Pink Fallot," bluing is not seen; in this type, there is a hole in the heart (Ventricular Septal Defect - VSD), but there is no significant narrowing in the right ventricular outflow tract (the path of blood from the heart to the lungs). Both blue (cyanotic) and pink Tetralogy of Fallot require open-heart surgery for definitive treatment.