Liver failure is classified as acute or chronic and can arise from various causes. The main causes of chronic liver failure include: Chronic Hepatitis B and C infections, Cirrhosis (an advanced stage of various liver diseases), Long-term excessive alcohol consumption, Obstructions in liver blood vessels, Certain nutritional deficiencies, Bile duct diseases such as Primary Sclerosing Cholangitis, Hereditary metabolic diseases (for example Hemochromatosis (iron metabolism disorder), Alpha-1 antitrypsin deficiency, Wilson's disease (copper metabolism disorder)). The main causes leading to acute liver failure are: Acute hepatitis caused by Hepatitis A, B, and C viruses, High-dose acetaminophen (a commonly used fever reducer and painkiller) usage, Severe reactions to certain herbal medicines, and Poisonous mushroom ingestion.