The treatment for Sjögren's syndrome primarily focuses on alleviating symptoms. For dry eyes, artificial tears and various eye drops are effectively used. In the management of dry mouth, regular gargling, meticulous oral hygiene, and keeping the mouth continuously moist are of great importance. Given the frequent occurrence of dental caries in these patients, measures such as chewing gum can help preserve oral health. In cases where systemic symptoms beyond dry eyes and dry mouth emerge, immunosuppressive drugs, particularly steroids, may be included in the treatment.

If other autoimmune diseases accompany Sjögren's syndrome, the treatment of these conditions is prioritized. Furthermore, individuals diagnosed with Sjögren's syndrome have an increased risk of developing lymphoma compared to the general population.