Proteins are vital macromolecules with many fundamental roles, such as providing energy, balancing body fluids, strengthening the immune system, and regulating various physiological processes. Normally, after completing their tasks, proteins are broken down or recycled and do not accumulate. Amyloidosis, also known as a protein misfolding disorder, occurs when certain proteins adopt an abnormal, insoluble shape and accumulate as amyloid deposits in organs and tissues. Systemic amyloidosis can affect many organs throughout the body, including the heart, kidneys, liver, digestive system, joints, skin, and blood vessels. In severe cases, these extensive amyloid deposits can lead to organ failure. Localized amyloidosis, on the other hand, typically targets specific areas such as the skin, bladder, and respiratory tract.