Various studies indicate that prolotherapy is effective for chronic, painful tendon issues resulting from aging or overuse of joints. Research suggests that prolotherapy can increase tendon strength by up to 40%. Clinical data further confirm its benefits in tendon and ligament injuries, and in alleviating pain associated with osteoarthritis. It is also known to be used in the treatment of many musculoskeletal conditions such as meniscal tears, tendinitis, ligamentitis pain, muscle and tendon swellings, lower back, neck, and back pain, headaches, and tennis elbow.