Individuals with Vascular Ehlers-Danlos syndrome (VEDS) may exhibit characteristic facial features including a thin nose, thin upper lip, and small earlobes. Their skin bruises easily and is often translucent. Particularly in fair-skinned individuals, blood vessels may be visible beneath the skin.

VEDS can weaken arteries throughout the body, including the aorta, the main artery emerging from the heart. The rupture of any of these vital blood vessels can lead to life-threatening consequences. Furthermore, vascular type Ehlers-Danlos syndrome can also weaken the walls of the uterus and large intestine, increasing the risk of rupture.