Liver cancer typically affects individuals over the age of 65. Risk factors for this type of cancer include gallstones in the bile duct, Hepatitis B and C virus infections, prolonged exposure to chemical substances, and diabetes. Other significant risk factors are:

* Hepatitis D virus infections
* Aflatoxin exposure (Aspergillus flavus toxin)
* Cirrhosis (liver cirrhosis)
* Genetic, congenital, and metabolic diseases (e.g., Hemochromatosis, Wilson's disease, Glycogen storage disease)
* Exposure to certain chemical substances (nitrites, hydrocarbons, solvents)