PFAPA syndrome is a common autoinflammatory disease in childhood. Its most prominent feature is recurrent, sudden-onset high fever attacks exceeding 38°C. These fever attacks typically occur every three to six weeks and usually last for three to five days. Other characteristic symptoms observed alongside high fever include swollen lymph nodes (adenitis), sore throat (pharyngitis), and mouth sores (aphthous ulcers).

Generally, the symptoms of PFAPA syndrome are as follows:
* Recurrent high fever attacks exceeding 38°C
* Swelling of lymph nodes in the neck (Adenitis)
* Sore throat (Pharyngitis)
* Mouth sores (Aphthous ulcers)
* White spots on the tonsils
* Headache
* Joint pain
* Skin rash
* Nausea and vomiting
* Diarrhea