Prompt and aggressive treatment is required for individuals diagnosed with mucormycosis. The cornerstone of this treatment consists of antifungal medications. Antifungal agents control the infection by stopping the growth of and damaging the fungi responsible for the infection.

Antifungal medications used in the treatment of mucormycosis can be administered intravenously (IV) or orally. Typically, in the initial phase of treatment, high-dose intravenous medications are applied to rapidly control the infection; this phase can last several weeks. Following the completion of intravenous therapy, oral antifungal medications may be transitioned to.

Due to the potent nature and high dosages of the antifungal drugs used, patients may experience various side effects. It is important for patients to promptly inform their healthcare provider if symptoms such as abdominal pain, heartburn, or shortness of breath occur.

In severe cases, surgical intervention may be necessary. This involves the removal of tissues severely damaged by the mucormycosis infection, aiming to prevent the spread of the infection to other parts of the body. Such operations may even include the removal of parts of organs like the nose, lungs, or eyes when clinically indicated. While these surgical procedures might lead to some alterations in patients' appearance, their critical role in controlling a life-threatening mucormycosis infection should not be overlooked.