Amputation is a surgical procedure performed under operating room conditions. The anesthesia method to be applied is determined according to the location of the limb to be amputated and the patient's general health status. For instance, arm or hand amputations are generally performed under general anesthesia, while some finger amputations can be carried out with local anesthesia. For leg or foot amputations, general anesthesia or spinal anesthesia (numbing below the waist) may be preferred.

Patients should generally refrain from consuming solid and liquid food for 8 hours before the surgery. Before being taken to the operating room, the limb to be amputated is marked by the surgeon, and the precise level of incision is clarified. In the operating room, after the patient is prepared, the limb is surgically removed from the planned area, completing the procedure.