Agoraphobia treatment is tailored to each individual, depending on the type and severity of the specific symptoms they experience. Treatment approaches typically include lifestyle changes such as exercise, relaxation techniques, establishing healthy sleep hygiene, identifying and managing stress factors, and spending time with social support groups (family and friends). Such approaches can help alleviate symptoms and improve quality of life. Most patients significantly benefit from psychological therapies, including cognitive behavioral therapy (CBT).

Generally, antidepressants are considered more effective than anti-anxiety medications in the treatment of agoraphobia. However, there are potential side effects that individuals should be aware of before starting medication. For instance, some antidepressants can lead to various side effects such as nausea, weight gain, fatigue, dizziness, irritability, increased anxiety, and decreased libido in adults.

As an effective alternative to medication, Cognitive Behavioral Therapy (CBT) has proven beneficial for many individuals suffering from agoraphobia. Through CBT, individuals can develop valuable skills to better manage and cope with anxiety-related symptoms.

Exposure Therapy is a popular and effective method in the treatment of agoraphobia. In this therapy, individuals are gradually and repeatedly confronted with the situations they fear most. This process leads to desensitization over time, enabling individuals to face these situations more confidently. For example, a person afraid to leave their home alone might start by stepping just outside their house or taking short walks around their home.

Treatment can be complicated by the difficulty patients may have in attending appointments due to their agoraphobia. For this reason, some therapists may choose to conduct initial sessions in patients' homes.