Body Mass Index (BMI) is calculated by dividing an individual's weight by the square of their height (kg/m²). A BMI above 30 kg/m² is defined as obesity and can negatively affect regular egg development in women. In individuals with obesity undergoing in vitro fertilization (IVF), the ovaries' response to hormone medications is generally lower, which can lead to a smaller number of eggs being retrieved.
Furthermore, the distribution of fat tissue in the body is also important. Central obesity, characterized by an increased waist-to-hip ratio, is associated with hormonal imbalances and insulin resistance, which can reduce the chances of conception.
To increase the chances of pregnancy and prevent obesity-related complications that may arise during pregnancy (e.g., hypertension, gestational diabetes, macrosomia, difficult labor, and postnatal infant-related issues), weight loss is recommended before starting fertility treatment. This process should be supported by endocrinological evaluation, an appropriate diet supervised by a dietitian, and regular exercise programs.