The treatment of lymphadenitis depends on its clinical presentation. In cases where lymph nodes are not excessively enlarged and are non-tender, antibiotic therapy is typically unnecessary, and clinical monitoring is advised. If, however, the lymph node continues to enlarge or an infection is suspected, antibiotic treatment is initiated. When persistent enlargement occurs without definitive signs of infection, a trial of empirical antibiotic therapy may be considered to assess for resolution, implying a potential underlying subclinical infection or inflammatory process. Should etiologies other than infection be suspected, a comprehensive diagnostic evaluation, including imaging, laboratory tests, and potentially tissue biopsy, is crucial to establish the cause before initiating targeted treatment.