The primary aim in treating spina bifida is to close the opening in the spinal cord. This is typically achieved through surgical intervention. As spina bifida presents with a broad clinical spectrum, a multidisciplinary approach is essential for its treatment. The collaboration of various medical specialties in formulating a treatment plan significantly enhances patients' quality of life.

In milder forms of the disease, treatment focuses on alleviating symptoms and reducing the effects of the condition. In such cases, physiotherapy and medication can be employed. Furthermore, patients may require ongoing supportive therapies throughout their lives to prevent and manage potential complications.