The diagnosis of Pica syndrome is made following a comprehensive clinical evaluation. Diagnostic criteria include the repetitive consumption of non-nutritive substances for at least one month, in a manner inconsistent with the individual's developmental level and not culturally accepted. Existing laboratory tests for Pica syndrome typically help identify complications caused by the condition or associated underlying medical issues.

In the treatment of Pica syndrome, the primary objective is to determine the underlying causes. If a nutritional deficiency is identified, the treatment plan involves regulating nutrition and providing necessary supplements. It is critically important for the pediatrician to collaborate with a multidisciplinary team, including social workers, dietitians, and psychologists, when necessary. Behavioral therapies can provide additional benefits for many children with Pica syndrome. Furthermore, if a developmental, neurological, or psychiatric disorder is suspected, consultation and support from relevant specialists are sought.