Cardiac development in the womb typically completes within the first 6 to 10 weeks of pregnancy. This means that by the time a woman learns she is pregnant, the baby's heart structure has largely formed. Various adverse factors encountered during this critical first 10 weeks of gestation can predispose to the development of congenital heart diseases. Particularly in genetically susceptible infants, exposure during this period to infections, radiation, electromagnetic fields, certain medications, or harmful substances (such as alcohol, illicit drugs, air pollution, etc.), as well as insufficient maternal nutrition, are considered potential risk factors for congenital heart conditions like Tetralogy of Fallot. However, definitive evidence-based information regarding the precise effects of these risk factors on Tetralogy of Fallot is not yet fully available. The emergence of the disease is generally a multifactorial process, shaped by the convergence of many factors.