Neurosurgical navigation systems are most commonly used in Neurosurgery for the following procedures:

Brain tumor surgery
Brain hemorrhage surgery
Surgery for arteriovenous malformations (AVMs)
Surgery involving deep brain stimulation, such as for Parkinson's disease and similar tremor disorders
Spine surgery and determining the trajectory of screws placed in the spine
Additionally, neurosurgical navigation systems may be used in some orthopedic surgeries.