Hepatitis B and C, cirrhosis (which can result from many diseases), long-term excessive alcohol consumption, blockage in certain liver blood vessels, nutritional deficiencies, some bile duct diseases (primary sclerosing cholangitis), certain hereditary diseases, hemochromatosis (iron metabolism disorder), alpha-1 antitrypsin deficiency, and Wilson's disease (copper metabolism disorder) cause chronic liver failure. Hepatitis due to Hepatitis A, B, and C viruses, high-dose acetaminophen (a common over-the-counter fever reducer and pain reliever) use, reactions to certain herbal remedies, and consumption of poisonous mushrooms cause acute liver failure.