While surgical biopsy methods were commonly used for disease diagnosis in the past, modern techniques have now replaced these approaches with minimally invasive procedures. Specifically, image-guided core needle biopsies allow tissue samples to be taken from a mass or tissue quickly, easily, and usually painlessly, without patients requiring anesthesia, hospitalization, or open surgery. This method provides the attending physician with highly accurate information regarding treatment planning or the scope of surgical intervention, aiding in definitive diagnosis. Significant advantages include offering a higher diagnostic accuracy rate compared to fine-needle aspiration (FNA), reducing the risk of inadequate sampling, and often eliminating the need for repeat biopsies. Furthermore, since it does not require a surgical incision, it leaves no aesthetic scarring.