Fabry disease is characterized by a diverse range of symptoms affecting various organ systems. Key manifestations include:
* Painful burning sensations, numbness, or tingling in the hands and feet.
* Intense muscle pain, especially during physical activity.
* Intolerance to heat or cold.
* Ocular abnormalities.
* Dizziness and fatigue.
* Flu-like symptoms, such as fever.
* Gastrointestinal issues, including constipation, diarrhea, or abdominal pain.
* High levels of protein in the urine (proteinuria).
* Hearing loss or tinnitus.
* Reddish-purple skin lesions (angiokeratomas).
* Edema (swelling).
Although more commonly observed in males, Fabry disease can also affect females. Untreated Fabry disease can lead to serious health complications, such as kidney failure, heart disease, hypertension, and osteoporosis.