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In patients with Familial Mediterranean Fever (FMF), frequent recurrent attacks can lead to the accumulation of an abnormal protein called amyloid in the body. This condition, especially the accumulation of amyloid in the kidneys (amyloidosis), can cause severe organ damage and kidney failure. Potential complications of FMF may include:
* Amyloidosis (Abnormal Protein Accumulation): During FMF attacks, the body may produce an abnormal protein called amyloid A. The accumulation of this protein in various organs leads to organ dysfunction and damage (amyloidosis).
* Kidney Damage: Amyloidosis can damage the kidneys, leading to nephrotic syndrome. Nephrotic syndrome occurs when the kidney's filtering systems (glomeruli) are damaged, resulting in a significant loss of protein in the urine. This condition can lead to blood clots in the kidneys (renal vein thrombosis) or kidney failure.
* Infertility in Women: Inflammation associated with FMF can affect female reproductive organs, leading to infertility.
* Joint Pain (Arthritis): Arthritis (joint inflammation) is a common complication in individuals with Familial Mediterranean Fever. The most commonly affected joints are the knees, ankles, hips, and elbows.
What are the Complications of Familial Mediterranean Fever (FMF)?
* Amyloidosis (Abnormal Protein Accumulation): During FMF attacks, the body may produce an abnormal protein called amyloid A. The accumulation of this protein in various organs leads to organ dysfunction and damage (amyloidosis).
* Kidney Damage: Amyloidosis can damage the kidneys, leading to nephrotic syndrome. Nephrotic syndrome occurs when the kidney's filtering systems (glomeruli) are damaged, resulting in a significant loss of protein in the urine. This condition can lead to blood clots in the kidneys (renal vein thrombosis) or kidney failure.
* Infertility in Women: Inflammation associated with FMF can affect female reproductive organs, leading to infertility.
* Joint Pain (Arthritis): Arthritis (joint inflammation) is a common complication in individuals with Familial Mediterranean Fever. The most commonly affected joints are the knees, ankles, hips, and elbows.