In the treatment of liver cancer, surgical removal of the tumor (resection) is generally the first method considered. The suitability of this approach depends on factors such as the tumor's stage, its spread within the liver, and the patient's overall liver health. If the tumor is not suitable for resection or meets specific criteria, liver transplantation may be considered as a treatment option. Liver transplantation, by completely replacing the diseased liver with a healthy one, is one of the most effective treatment methods that significantly reduces the risk of tumor recurrence. In cases where surgical options are not possible or as a complementary treatment, various localized and systemic treatment methods are applied. These methods include ablation (burning or freezing the tumor), embolization, radiation therapy, targeted drug therapy, immunotherapy, and chemotherapy. These treatments aim to destroy cancer cells or control their growth. However, if the cancer has spread outside the liver (metastasis), surgical treatment is generally not appropriate; in this situation, systemic treatments come to the forefront.