The primary goal of chondromalacia patella treatment is to reduce stress on the kneecap. In cases of acute symptom exacerbation, rest, cold application (15 minutes, 4-5 times a day for several days), and the use of a knee brace may be recommended. Non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed for several weeks due to their pain-relieving and anti-edematous effects.

A crucial part of the treatment involves strengthening the muscles around the knee through exercise to enhance knee stability. It is critical for the anterior, posterior, medial, and lateral thigh muscles to possess balanced strength and flexibility to ensure optimal patellar alignment. Low-impact sports such as swimming and exercise biking are suitable for strengthening muscles without excessive loading. Additionally, special taping techniques like Kinesio tape can correct patellar positioning, and orthoses such as knee braces or insoles may be utilized.

Among regenerative medicine approaches, PRP (Platelet-Rich Plasma) and stem cell injections can support the cartilage tissue's repair process. In situations where conservative treatment methods do not yield satisfactory results, surgical options may be considered. These options include procedures such as releasing certain ligaments that stabilize the kneecap, debridement (shaving) to address cartilage surface irregularities, or cartilage tissue grafting.