Various potential side effects may occur during PUVA treatment. These can generally be grouped as follows:

* General and Short-term Side Effects: Skin itching, headache, nausea, vomiting.
* Side Effects Observable in Long-term Treatments: Skin dryness, spots, darkening of skin tone, freckling, and skin aging.
* Other Side Effects: Elevated liver enzymes and the triggering of herpes infections in some individuals.