Knee prosthesis (knee joint replacement surgery) is a treatment method applied to patients experiencing advanced joint wear, medically known as osteoarthritis. Although commonly referred to as "kireçlenme" (calcification) in Turkish, often mistakenly associated with mineral buildup, it actually refers to the deterioration of articular cartilage.

The ends of our bones are covered by articular cartilage, a firm, smooth, and shiny tissue that allows for effortless joint movement. Over time, due to various reasons such as aging, infections, traumas, or rheumatic diseases, this vital cartilage tissue can wear down. As the cartilage structure wears or tears, the bones begin to rub directly against each other, leading to the symptoms and progression of osteoarthritis.

The main conditions that lead to severe joint deterioration necessitating knee replacement surgery are:
* Primary Osteoarthritis: This is the most common cause, characterized by progressive wear and tear of the knee joint without a clear underlying reason.
* Rheumatic Diseases: Conditions like rheumatoid arthritis can cause significant joint damage.
* Post-traumatic Arthritis: Intra-articular fractures or severe injuries can lead to long-term cartilage damage.
* Post-infectious Arthritis: Previous joint infections can severely damage the cartilage, leading to advanced wear.

Knee prosthesis is considered an option for patients who suffer from severe pain, restricted movement, grinding sensation, clicking sounds from the knee, or difficulty walking due to advanced knee cartilage wear, and who have not received adequate benefit from conservative treatments such as physical therapy, intra-articular injections (e.g., PRP, stem cell therapy).