Long-term use of corticosteroid treatment can lead to various systemic side effects. However, single-dose or short-term applications generally do not carry severe side effects. In individuals with hypertension or diabetes, temporary increases in blood pressure or fluctuations in blood sugar, lasting one to two days, may rarely occur. While there is a theoretical risk of bleeding with injection therapies, this risk is generally not significant due to the absence of major vessels in the application area.