If a doctor suspects penile cancer, they will recommend a biopsy for definitive diagnosis. A biopsy involves taking a small tissue sample from the penis or lymph nodes for detailed examination in a laboratory. This procedure aims to confirm the presence and type of cancer cells. Generally, three main types of biopsy are available: Incisional biopsy: In this method, only a portion of the abnormal-looking tissue is surgically removed. It is typically applied for larger lesions, wounds, ulcerations, or lesions thought to have spread deeper into the tissue.