The treatment of atherosclerotic plaques primarily involves cholesterol-lowering and blood-thinning medications. Controlling risk factors is paramount for effective management. Cholesterol medications play a significant role in reducing and stabilizing plaques. While age, gender, and genetic predisposition are unmodifiable factors, controlling modifiable risk factors such as hypertension (high blood pressure), diabetes, and smoking is crucial for treatment success. It is essential to manage hypertension, maintain a healthy weight, control diabetes, and cease smoking. Patients with hypertension and diabetes must adhere to their medication regimens consistently.