Nanoknife ablation therapy is a significant option for patients with pancreatic cancer who are not candidates for surgical resection. This method aims to target and destroy the tumor without causing damage to sensitive surrounding tissues such as blood vessels, nerves, and intestines. Pancreatic cancer is one of the primary application areas for this treatment. The most suitable patient group for Nanoknife consists of patients with locally advanced pancreatic cancer who do not have distant metastases but are unresectable due to involvement of surrounding blood vessels. In these patients, Nanoknife can ablate the tumor tissue without harming the involved vascular structures. This can potentially make patients eligible for surgery again or contribute to prolonging their lifespan by reducing tumor size.