Peptic ulcer is a sore that develops in the stomach, duodenum, or sometimes the esophagus. It is generally more common in the initial part of the duodenum and in the stomach. Symptoms may include hunger pain, abdominal pain that can awaken one at night and radiate to the back, a burning sensation, indigestion, and general discomfort. These pains typically intensify when the stomach is empty, between meals, or after eating, and can last from a few minutes to several hours. Fasting is a significant factor that adversely affects the course of duodenal ulcers in particular. During Ramadan, a noticeable increase in severe complications such as ulcer pain escalation, bleeding, or perforation is observed. Indeed, a significant rise in the number of patients admitted to hospitals due to ulcer perforation or bleeding is reported during this period. In this context, it is recommended that patients with peptic ulcers refrain from fasting, or only fast under strict medical supervision and with special precautions.