The primary goal of treatment for Premenstrual Syndrome (PMS) is to alleviate symptoms, improve social and occupational functioning, and thereby enhance overall quality of life. Treatment approaches generally fall into two categories: biological (pharmacological interventions) and psychological (psychotherapy).

Psychological Approaches
For women with mild symptoms, psychoeducation and lifestyle adjustments are often sufficient. Additionally, exercise, relaxation techniques, and cognitive-behavioral therapy (CBT) are recommended. These non-pharmacological methods can effectively alleviate premenstrual symptoms.

Pharmacological Treatment
The most commonly prescribed medications for PMS are selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants believed to act on serotonin pathways involved in the pathophysiology of PMS. SSRIs can be administered using two main strategies: intermittent dosing during the luteal phase (the last two weeks of the menstrual cycle) or continuous daily use. Intermittent use typically involves starting the medication around ovulation and discontinuing it one to two days after menstruation begins.

Contraceptive Pills
If premenstrual symptoms develop or worsen after initiating contraceptive pill use, switching to an alternative formulation or a different birth control method may be beneficial.

Hormonal Therapy
Another biological treatment option for PMS involves hormonal therapies. These strategies are based on the premise that premenstrual symptoms are linked to hormonal fluctuations during the menstrual cycle, and their primary goal is often to suppress ovulation.

Nutrition and Lifestyle Modifications
While certain dietary supplements are suggested for PMS, scientific evidence supporting their effectiveness is generally limited, with a few exceptions. Patients are also advised to prioritize sleep, reduce intake of caffeine, salt, nicotine, and alcohol, and consider supplements like Vitamin B6, magnesium, calcium, and Vitamin D during the symptomatic phase of PMS. Promising agents include calcium supplementation, Vitamin B6 (pyridoxine) supplementation, and if accompanied by pelvic pain, Vitamin B1 and Vitamin E. Additionally, a diet rich in complex carbohydrates and the use of Vitex agnus castus (Chasteberry) are noted. Studies have shown a reduction in psychiatric symptoms in women taking 80 mg of Vitamin B6 daily. Vitex agnus castus is thought to act as a dopamine agonist, reducing follicle-stimulating hormone (FSH) or prolactin levels, and is considered beneficial more for the physical symptoms of PMS than the psychological ones.