Liver cancer risk factors cover a broad spectrum and are generally more common in individuals over 65 years of age. The primary risk factors contributing to the development of this type of cancer include:

* Chronic Viral Hepatitis Infections: Long-term infections with Hepatitis B, Hepatitis C, and especially Hepatitis D viruses significantly increase the risk of liver cancer.
* Cirrhosis: Cirrhosis, resulting from chronic liver damage and inflammation, is a fundamental underlying factor in most cases of liver cancer.
* Metabolic and Genetic Diseases: Conditions such as diabetes, hemochromatosis (iron accumulation), Wilson's disease (copper accumulation), and certain glycogen storage diseases can elevate the risk of liver cancer.
* Exposure to Toxins and Chemical Substances: Exposure to environmental toxins like aflatoxin produced by the Aspergillus flavus fungus, or long-term contact with specific chemical substances such as nitrites, hydrocarbons, and solvents, can increase the risk.
* Gallstone Disease: The presence of stones in the bile ducts can also be among the risk factors.