Diagnosis of esophageal cancer, stomach cancer, rectal cancer, bile duct cancer, and pancreatic cancer; biopsy; early detection of cancer; investigation of recurrence findings in post-operative follow-up; examination of cancer involvement in lymph nodes and vessels in neighboring organs around the rectum (prostate, bladder, vagina); and determination of tumor stage (T1, T2, T3, T4).

Gastrointestinal stromal tumors (GISTs), leiomyomas, and other tumors originating from the walls of organs such as the esophagus, stomach, and rectum; detection of submucosal lesions.

Biopsy of intra-abdominal lymph nodes.

Anal fistula: Diagnosis and classification; understanding the relationship of the fistula to the anal sphincter muscles.

Fecal and gas incontinence: Assessment of the thickness and condition of the anal canal muscles.

Pancreatitis: Detection and drainage of pseudocysts and necrotic tissues (in cases of necrotizing pancreatitis) around the pancreas in acute pancreatitis cases; assessment of the pancreas and pancreatic duct in chronic pancreatitis.

EUS-guided pain management in pancreatic cancer.

Biopsy of liver lesions.

EUS-guided drainage or stenting of bile ducts obstructed due to cancer into the stomach or small intestine.