Aramaya Dön
EN
First, it must be stated that there is no definitively known cause of AML. It is more accurate to categorize the causes of acute myeloid leukemia under two main headings:
Genetic causes
The effect of environmental factors
When we say genetic causes, we do not generally mean congenital or hereditary causes. The genetic disorders that arise in these diseases are largely acquired later in life. They can occur in one or several of the genes that make up the chromosomes. Sometimes genetic disorders can also be seen in the form of chromosome breakage, with the broken piece being placed on another chromosome. This can cause the cell to become cancerous and to have the ability to proliferate excessively, leading to the development of leukemia.
Among the most common environmental factors are high-dose radiation exposure (generally appearing many years after this exposure), smoking, or certain chemicals that damage the structure of cells. Besides these, it is known that the frequency of leukemia occurrence increases in the course of certain blood diseases that we can describe as bone marrow sluggishness. Leukemia can occur in later years in patients who have received chemotherapy for any type of cancer. Certain microbes, which we call viruses, can trigger the development of leukemia.
What are the causes of acute myeloid leukemia (AML)?
Genetic causes
The effect of environmental factors
When we say genetic causes, we do not generally mean congenital or hereditary causes. The genetic disorders that arise in these diseases are largely acquired later in life. They can occur in one or several of the genes that make up the chromosomes. Sometimes genetic disorders can also be seen in the form of chromosome breakage, with the broken piece being placed on another chromosome. This can cause the cell to become cancerous and to have the ability to proliferate excessively, leading to the development of leukemia.
Among the most common environmental factors are high-dose radiation exposure (generally appearing many years after this exposure), smoking, or certain chemicals that damage the structure of cells. Besides these, it is known that the frequency of leukemia occurrence increases in the course of certain blood diseases that we can describe as bone marrow sluggishness. Leukemia can occur in later years in patients who have received chemotherapy for any type of cancer. Certain microbes, which we call viruses, can trigger the development of leukemia.