A Pap smear is a screening test. It cannot provide definitive information. Therefore, in suspicious cases, a cervical biopsy is performed for definitive diagnosis.

Tissue obtained through a cervical biopsy is sent to pathology. The examination of the biopsy tissue results in 5 different reports:

1. Normal cells: Although smear results may show cellular abnormalities, sometimes the biopsy result may be reported as clean. In this case, repeating the Pap smear after 3-6 months is sufficient.

2. CIN-1: The Pap smear should be repeated after 3-4 months.

3. CIN-2

4. CIN-3: If CIN-2 or CIN-3 is detected in the Pap smear, the top layer of the cervix is removed using a LEEP procedure. This tissue is about the size of a thumbnail. It is sent to pathology.

5. Cervical Cancer: If cervical cancer is diagnosed as a result of the cervical biopsy, removal of the uterus, lymph node biopsy, radiation therapy, and chemotherapy (drug treatment) are required.