Before a lip filler procedure, a healthcare professional applies a topical anesthetic cream to the lips or administers local anesthesia inside the lip. This ensures the lips are numb and no pain is felt. Once numbness is achieved, the filler is injected into designated areas of the lip using a fine needle or cannulas (blunt-tipped needles). This procedure, which has immediate visible effects, is short. To minimize swelling and bruising, the practitioner may apply cold compresses to the lips throughout the procedure.

Lip filler application requires skill and knowledge and must be performed by expert medical professionals. The procedure should be tailored to the patient's needs and the physician's recommendations following a consultation.