Agoraphobia can develop at any age; however, symptoms typically appear between the ages of 25 and 35, and affect women more often than men.

Individuals who feel they have experienced discrimination are thought to be at a higher risk of suffering from a range of anxiety disorders, including agoraphobia.

A history of panic attacks is also a risk factor for developing agoraphobia. Agoraphobic individuals are also at risk of experiencing panic attacks. Other anxiety disorders that tend to co-occur with agoraphobia include social anxiety disorder (social phobia) and generalized anxiety disorder.

Risk factors for agoraphobia may include:

Individuals with a history of panic attacks
Individuals with an anxious/nervous temperament
Individuals with a family history of agoraphobia or panic disorder
Stressful life events such as abuse, the death of a parent, being assaulted, or a child experiencing bullying
Environmental stressors including trauma (physical or emotional), unemployment, and low socioeconomic status
Struggling with other phobias