Prolotherapy is a complementary treatment that involves injecting proliferative solutions to stimulate the regeneration of weakened, worn, or damaged tendons, ligaments, and joints. During the procedure, solutions containing substances derived from natural sugars, such as dextrose or mannitol, are precisely injected into the affected areas. These substances induce a localized inflammatory response in the joints and at the entheses (where tendons and ligaments attach to bone). This controlled inflammation stimulates the body's natural healing processes, leading to the strengthening and regeneration of these connective tissues. For instance, prolotherapy is commonly applied to address various knee-related issues.