PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis) syndrome is a chronic autoinflammatory condition primarily observed in childhood. It is characterized by recurrent episodes of high fever, aphthous ulcers (mouth sores), pharyngitis (sore throat), and cervical adenitis (swollen lymph nodes in the neck). The exact trigger for PFAPA is currently unknown. Outside of regions with a high prevalence of Familial Mediterranean Fever (FMF), PFAPA is recognized as the most common cause of periodic fever syndromes in children.