Untreated low-grade uterine prolapse can progress to more advanced stages over time due to the worsening of permanent damage to the connective tissue and pelvic floor. For instance, a prolapse starting at stage 1 can advance to stage 4 if left untreated. In patients with long-term stage 4 uterine prolapse, the mucous membrane covering the prolapsed tissue may show ulcerations and thickening; furthermore, the prolapsed tissue may enlarge to an extent that it cannot be repositioned (reduced).