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Familial Mediterranean Fever (FMF) can lead to various serious complications as a result of frequently recurring attacks. These complications typically begin with the accumulation of an abnormal protein called amyloid in the body (amyloidosis) and may include the following conditions:
* Amyloidosis and Organ Damage: During FMF attacks, the amyloid A protein produced can accumulate in the body and damage organs. Its accumulation, especially in the kidneys, can lead to severe kidney damage.
* Kidney Damage and Failure: Amyloidosis affecting the kidneys can cause nephrotic syndrome. This syndrome occurs when the kidney's filtering systems (glomeruli) are damaged, leading to a significant loss of protein in the urine. Nephrotic syndrome can progress to more serious problems such as blood clots in the kidneys (renal vein thrombosis) or kidney failure.
* Infertility in Women: Chronic inflammation associated with FMF can affect female reproductive organs, leading to infertility.
* Joint Pain (Arthritis): Arthritis is quite common in individuals with Familial Mediterranean Fever. The most frequently affected joints are the knees, ankles, hips, and elbows.
What are the Complications of Familial Mediterranean Fever (FMF)?
* Amyloidosis and Organ Damage: During FMF attacks, the amyloid A protein produced can accumulate in the body and damage organs. Its accumulation, especially in the kidneys, can lead to severe kidney damage.
* Kidney Damage and Failure: Amyloidosis affecting the kidneys can cause nephrotic syndrome. This syndrome occurs when the kidney's filtering systems (glomeruli) are damaged, leading to a significant loss of protein in the urine. Nephrotic syndrome can progress to more serious problems such as blood clots in the kidneys (renal vein thrombosis) or kidney failure.
* Infertility in Women: Chronic inflammation associated with FMF can affect female reproductive organs, leading to infertility.
* Joint Pain (Arthritis): Arthritis is quite common in individuals with Familial Mediterranean Fever. The most frequently affected joints are the knees, ankles, hips, and elbows.