Assisted Reproductive Technologies (ART)

Assisted Reproductive Technologies encompass various methods used in the treatment of infertility. The main applications are as follows:

1. In Vitro Fertilization (IVF) – Classic IVF:
This method is commonly known as classic in-vitro fertilization. Unlike insemination, eggs collected from the woman are combined in a laboratory setting with sperm obtained from the man, which has been purified from dead cells and waste through special procedures (washing, etc.). Fertilization (conception) is expected to occur in its natural course, with the sperm reaching the egg by its own movement. This method is preferred in cases where sperm functions are somewhat preserved.

2. Intracytoplasmic Sperm Injection (ICSI) – Microinjection:
In this technique, also known as microinjection, sperm retrieved from the man are examined in detail under a high-magnification microscope. A single, morphologically most suitable and motile sperm is selected and directly injected into the cytoplasm of the egg collected from the woman using a micropipette. For the past 25 years, it has become a widely applied standard method, especially in the treatment of male factor infertility.

3. Intracytoplasmic Morphologically Selected Sperm Injection (IMSI):
IMSI is an advanced version of the ICSI method. While in classic ICSI, sperm are evaluated at approximately 400x magnification, IMSI utilizes special microscopes to magnify sperm up to 7200 times, offering a much more detailed examination. This high magnification allows for the detection of small structural abnormalities, particularly in the head structure of the sperm, which might go unnoticed at lower magnifications. This enables the selection of genetically and morphologically healthier sperm.

The IMSI method is considered an important tool to increase treatment success in the following situations:
* In patients with severe sperm morphology or motility problems and/or where a limited number of eggs can be retrieved.
* In couples who have experienced recurrent failures in previous IVF attempts.
* Especially in cases where infertility issues linked to sperm quality are identified.