Untreated Pica syndrome can lead to serious health problems. Major complications include digestive system disorders, which can manifest as constipation, bowel obstruction, or perforation. Enamel loss and wear on teeth, as well as parasitic infections resulting from ingested materials, are also common issues. Furthermore, Pica syndrome can lead to poisonings due to the ingestion of various toxic substances, especially lead. Lead poisoning can manifest with severe symptoms such as altered consciousness, seizures, and severe gastrointestinal symptoms.