Progeria, also known as Hutchinson-Gilford syndrome or premature aging disease, is a rare genetic disorder caused by a mutation in the LMNA gene. It leads to signs of early and rapid aging in affected children. The disease significantly shortens individuals' lifespan and increases the risk of serious cardiovascular events such as heart attack and stroke, often leading to death due to complications of severe atherosclerosis.
Although atherosclerosis is a common heart condition affecting millions of adults, it is also observed in young individuals with progeria. This condition is characterized by the accumulation of plaque on the inner walls of the arteries. Plaque buildup reduces the elasticity of the arteries and obstructs blood flow, setting the stage for fatal complications like heart attack or stroke.