The Alanine Aminotransferase (ALT) test is an important blood test used to assess liver health. A reference range is generally considered to be <41 U/L. Elevated ALT levels found above this value can indicate damage or disease in the liver.

Key conditions that can lead to elevated ALT include fatty liver disease, excessive alcohol consumption, obesity, diabetes, the use of certain medications, viral infections such as hepatitis A, B, and C, cirrhosis, bile duct obstructions, malignancies (cancers), heart failure, thyroid disorders, and celiac disease.

Some types of liver disease can cause ALT levels to rise in the bloodstream before noticeable symptoms appear. Therefore, an ALT blood test can play a critical role in the early diagnosis of certain liver conditions.

Common symptoms that may accompany high ALT levels include: Nausea and vomiting, fatigue, abdominal pain or cramps, loss of appetite, dark urine, skin itching, jaundice, and swelling in the ankles.