During a biopsy procedure, mild sedation may be preferred to enhance patient comfort. However, in some methods, such as standard or blind biopsies, the patient may be asked to follow breathing instructions like "breathe in, breathe out" during the procedure and "hold your breath" when the sample is taken. These types of biopsies generally do not require general anesthesia (full sleep). For targeted biopsies (e.g., those performed under ultrasound or CT guidance), where a specific lesion needs to be accessed precisely, sedation is a more common approach to ensure patient comfort and immobility.