Anisocoria treatment is determined and applied after diagnosing the cause of the condition. If it's physiological anisocoria, meaning it's not caused by another underlying disease, treatment may not be necessary. If it's pathological, then treatment is determined accordingly. Possible treatment methods for anisocoria include:

Surgical intervention may be necessary if a tumor is causing nerve compression.
If there's an eye injury, surgical intervention or medication may be used depending on the severity.
In cases like glaucoma, medications or surgical treatments are used to control intraocular pressure.
If anisocoria has developed due to a medication, changing the medication or adjusting the dosage may be necessary.
If it's caused by migraines or cluster headaches, migraine treatment is applied.
If there's inflammation in the body, anti-inflammatory medications such as antibiotics, antiviral drugs, or steroids may be used.