Response to steroid treatment during fever attacks is considered an important diagnostic criterion. Throat cultures in these patients typically do not show growth of beta-hemolytic streptococcus; however, its presence does not rule out the syndrome. PFAPA diagnosis should be considered in a child experiencing at least three regular, periodic fever attacks lasting less than seven days. These attacks should be accompanied by pharyngitis and painful throat swelling or aphthous ulcers in the mouth. Additionally, the child should exhibit normal growth and development, appear healthy between attacks, and show symptom resolution after a single dose of steroid treatment, which are all diagnostic clues. Fever attacks generally last 4-8 years; their frequency decreases as the child grows, eventually resolving spontaneously.