The diagnosis of Orf disease primarily begins with a careful evaluation of the patient's complaints and symptoms, followed by a physical examination. In cases of clinical suspicion, microscopic examination of samples taken from the wound tissue can aid in diagnosis. For a more definitive diagnosis, laboratory tests such as viral swabs, electron microscopy, or skin biopsy may be performed. The definitive diagnosis of Orf disease is typically confirmed by a PCR (polymerase chain reaction) test. To prevent confusion with other diseases presenting similar symptoms, such as anthrax, it is crucial that the diagnostic process is carried out meticulously.